张鹏 特聘研究员

职称职务： 特聘研究员

学科专业： 生物化学与分子生物学

研究方向：非酒精性脂肪肝病/肝癌的发病机制研究

实验室位置：

Email： zhp@whu.edu.cn

学习经历

2002.09-2006.06 佳木斯大学 生物科学 学士

2007.09-2010.06 兰州大学 动物学 硕士

2010.09-2014.06 上海交通大学 遗传学 博士

主要工作经历与任职

2015.07-2017.07 亚洲bet356体育官网app下载 博士后

2017.08-2020.08 武汉大学中南医院 医学科学研究中心 助理研究员

2020.09-至今  亚洲bet356体育官网app下载 特聘研究员

目前主要科学研究领域和兴趣

主要研究方向为非酒精性脂肪肝病/肝癌的发病机制研究。以小鼠等模式动物为研究对象，建立非酒精性脂肪肝炎/肝癌动物疾病模型，应用RNA-Seq、蛋白质组学等多组学联合及分子生物学方法，探究非酒精性脂肪肝炎及肝癌的发病机制，为寻找非酒精性脂肪肝炎/肝癌潜在治疗靶点和预防措施提供理论基础。先后主持国家级及省部级项目4项，发表研究论文13篇。

主要学术兼职

无

教学情况

参与本科生《实验动物学》课程教学，参与研究生《高级生物化学实验课》课程教学

荣誉及获奖

无

 代表性论文（近5年，10篇以内的第一作者或通讯作者论文）

1. Tu C^#, Xiong H^#, Hu Y^#, Wang W, Mei G, Wang H, Li Y, Zhou Z, Meng F, Zhang P*, Mei Z*. Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation. Hepatology. 2020:72(6):1949-1967.

2. Liu D^#, Zhang P^#, Zhou J^#, Liao R^#, Che Y, Gao MM, Sun J, Cai J, Cheng X, Huang Y, Chen G, Nie H, Ji YX, Zhang XJ, Huang Z, Xu H*, She ZG*, Li H*. TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation. Cell Metab. 2020:31(4):726-740.e8.

3. Zhang P^#, Zhu L^#, Cai J^#, Lei F^#, Qin JJ^#, Xie J, Liu YM, Zhao YC, Huang X, Lin L, Xia M, Chen MM, Cheng X, Zhang X, Guo D, Peng Y, Ji YX, Chen J, She ZG, Wang Y, Xu Q, Tan R, Wang H, Lin J, Luo P, Fu S, Cai H, Ye P, Xiao B, Mao W, Liu L, Yan Y, Liu M, Chen M, Zhang XJ, Wang X, Touyz RM, Xia J, Zhang BH, Huang X, Yuan Y*, Rohit L*, Liu PP*, Li H*. Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19. Circ Res. 2020:126(12):1671-1681.

4. Tong J^#, Han CJ^#, Zhang JZ^#, He WZ, Zhao GJ, Cheng X, Zhang L, Deng KQ, Liu Y, Fan HF, Tian S, Cai J, Huang Z, She ZG, Zhang P*, Li H*. Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator-Activated Receptor γ in Mice. Hepatology. 2019:69(6):2471-2488.

5. Gong J^#, Fang C^#, Zhang P^#, Wang PX, Qiu Y, Shen LJ, Zhang L, Zhu XY, Tian S, Li F, Wang Z, Huang Z, Wang A*, Zhang XD*, She ZG*(2018). Tumor progression locus 2 in hepatocytes potentiates both liver and systemic metabolic disorders in mice. Hepatology. 2019;69(2):524-544.

6. Zhao GN^#, Zhang P^#, Gong J^#, Zhang XJ^#, Wang PX, Yin M, Jiang Z, Shen LJ, Ji YX, Tong J, Wang Y, Wei QF, Wang Y, Zhu XY, Zhang X, Fang J, Xie Q, She ZG, Wang Z, Huang Z, Li H*. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat Med. 2017:23(6):742-752.

7. Zhang P^#, Hou S^#, Chen J^#, Zhang J, Lin F, Ju R, Cheng X, Ma X, Song Y, Zhang Y, Zhu M, Du J, Lan Y*, Yang X*. Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm. Circ Res. 2016:118(3):388-99.

8. Ji YX^#, Zhang P^#, Zhang XJ^#, Zhao YC, Deng KQ, Jiang X, Wang PX, Huang Z, Li H*. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signaling. Nat Commun. 2016:1;7:11267.